In vitro antiviral activities of Chinese medicinal herbs against duck hepatitis B virus |
| |
| Authors: | Leung K T Chiu Lawrence C M Lam W S Li Yaolan Sun Samuel S M Ooi Vincent E C |
| |
| Affiliation: | Natural Product and TCM Pharmacology Research Laboratory, Department of Biology, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, People's Republic of China. |
| |
| Abstract: | Fifty-six different Chinese medicinal herbs from 29 families were evaluated for their antiviral activities against duck hepatitis B virus (DHBV) in vitro. The DHBV DNA level in primary duck hepatocyte cultures was monitored by dot blot hybridization and the cytotoxicity was evaluated by MTT assay. Anti-DHBV activities were found more strongly in the aqueous extracts of Ardisia chinensis and Pithecellobium clypearia with selective indices of 2.6 and >2.7, respectively, which were comparable to that of 2',3'-dideoxycytidine. Further research on the isolation of the active antiviral phytochemicals from these herbs may provide alternative options for the treatment of chronic hepatitis B. |
| |
| Keywords: | Chinese medicinal herbs antiviral duck hepatitis B virus |
| 本文献已被 PubMed 等数据库收录！ |
|
