| Antineoplaston A10的衍生物—N2—苯乙酰基—N—取代—L—谷氨酰胺的合成 |
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| 引用本文： | 杨善彬,金初rong.Antineoplaston A10的衍生物—N2—苯乙酰基—N—取代—L—谷氨酰胺的合成[J].华西药学杂志,1991,6(2):72-74. |
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| 作者姓名： | 杨善彬 金初rong |
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| 作者单位： | 华西医科大学药学院，华西医科大学药学院 成都 610041 1990届硕士研究生 重庆西南制药三厂，成都 610041 |
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| 摘 要： | 以1-谷氨酸为起始原料经酯化、酰化、肼解、叠氮化和酰胺化获得题目化合物I。这些化合物经元素分析、红外光谱、核磁共振氢谱和质谱加以确证。除化合物Ic和Ih外,其余尚未见文献报道。它们将在小鼠中作抗肿瘤活性试验。
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| 关 键 词： | 哌啶二酮类 谷氨酰胺类 合成 |
SYNTHESIS OF N~2-PHENYLACETYL-N-SUBSTITUTED-L-GLUTAMINES AS DERIVATIVES OF ANTINEOPLASTON AIO |
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| Yallg Shanbin Jin Churong.SYNTHESIS OF N~2-PHENYLACETYL-N-SUBSTITUTED-L-GLUTAMINES AS DERIVATIVES OF ANTINEOPLASTON AIO[J].West China Journal of Pharmaceutical Sciences,1991,6(2):72-74. |
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| Authors: | Yallg Shanbin Jin Churong |
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| Abstract: | L-glutamic acid was used as starting material by est erification,acylation and reaction with hydrazine hydrate afforded hydrazine derivative,then introduction of azide group yielded azide derivatve. Finally,the title compounds (I)were synthesized by am idation.These compo unds have been verified by EA,lR,HNMR and MS.Among them every compound excepted Ic and lh,has not been reported.These synthetic compounds will be tested for antineoplastic activities in rats. |
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| Keywords: | Antineoplaston A10 Antineoplastic activity Substituted-1-glutamines |
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