正常妊娠及妊娠期高血压疾病孕妇凝血、抗凝、纤溶指标检测的临床意义

目的 研究凝血、抗凝、纤溶指标在妊娠中的变化，探讨其在妊娠期高血压疾病诊断和预防中的价值。方法检测血浆凝血酶原时间（P，r）、活化部分凝血活酶时阃（脚）、纤维蛋白原（nB）、抗凝血酶Ⅲ（AT-Ⅲ）、凝血因子VIII活性（VI—II：C）、D-二聚体（D—D）六项血凝指标共86例，其中妊娠期高血压疾病患者30例，正常晚孕组36例，正常非孕妇女20例，并对检测结果进行比较分析。结果妊娠期胛、APIT均缩短，且妊娠期高血压疾病患者与正常非孕妇比较差异有统计学意义（P〈0．05）；妊娠期高血压疾病患者和正常孕妇AT—Ⅲ明显低于正常非孕妇女（P〈0．001、P〈0．01）；VⅢ：C、FIB、D—dimer妊娠期高血压疾病患者和正常孕妇均明显高于正常非孕妇女（P〈0．001、P〈0．01）。结论正常孕妇处于高凝状态，妊娠期高血压疾病患者有血栓形成倾向，产前做凝血、抗凝、纤溶指标的检测对预防和治疗妊娠期高血压疾病的发生和发展有重要临床意义。

Clinical significance of coagulation, anticoagulation and fibrinolytic index detection in pregnant woman of norreal pregnancy and hypertensive disorders in pregnancy

Objective To study the level and clinical significance of coagulation, anticoagulation and fibrinolytic index in pregnancy. Methods To detect of plasma prothrombin time （PT）, activated partial thromboplastin time （AFTT）, fibrinogen （FIB）, antithrombin Ⅲ （AT - m）, coagulation factor Ⅷ activity （VIII： C）, D - dimer （D - D） in 86 cases including 30 women with hypertensive syndrome, 36 normal pregnancy and 20 non - pregnancy. Results The PT and AVTT of women with gestational hypertension were shorter than those of non - preg- nancy women（ p 〈 0.05） ; AT - Ⅲ of women with gestational hypertension and normal pregnancy were lower than that of non - pregnancy women（ P 〈 0.001, P 〈 0.01 ）; VIII ：C, FIB, D- dimer of women with gestational hypertension and normal pregnancy were significantly higher than that of non - pregnancy women（ P 〈 0. 001, P 〈 0.01 ）. Conclusion Women with normal pregnancy and gestational hypertension were in hypercoagulable state and thrombosis. Antenatal examination of coagulation, anticoagulation and fibrinolytic index has high value in prevention and treatment of hypertensive syndrome of pregnancy