同型半胱氨酸、超敏C反应蛋白与冠心病关系的研究

目的 探讨血清同型半胱氨酸（Hcy）、超敏c反应蛋白（hs—CRP）与冠心痛（CHD）的关系。方法收集本院169例冠心病患者血清为观察组，其中稳定性心绞痛42例（SAP组），不稳定性心绞痛62例（UAP组），急性心肌梗死65例（AMI组），以62例健康人血清为对照组，测定Hcy、hs—CRP的水平。结果CHD患者Hcy和hs—CRP水平与对照组相比显著增高，SAP、UAP、AMI3组Hey比较，水平依次升高，且差异有统计学意义（P〈0．05）；AMI组、UAP组和SAP组hs—CRP水平相比，差异有统计学意义（P〈0．05），但AMI纽和UAP组两组间差异无统计学意义（P〉0．05）。Hcy单独检测的CHD诊断敏感度为64．12％，特异度56．46％；hs—CRP单独检测敏感性为70．42％，特异度为44．76％；两者联合检测敏感度为88．05％，特异度为80．64％，明显高于单独检测（P〈0．05）。结论Hcy、hs—CRP是冠心病的独立危险因素，两者同时检测对可冠心病的诊断的重要价值。

The study on correlation between serum homocysteine, hyper sensitive C - reactive protein and coronary heart disease

Objective To study the correlation between serum homocystein （Hcy）, hyper sensitive C - reactive protein （hs - CRP） and coronary heart disease （CHD）. Methods 169 CHD patients were divided into 3 groups, including 42 eases of stable angina （SAP）, 62 cases of unstable angina （ UAP）, 65 cases of acute myocardial infarction （AMI）, and control group consisted of 62 healthy people. The level of hs - CRP and Hcy was measured. Results The levels of Hcy and hs - CRP were significantly higher in CHD patients than those in control group （ P 〈 0. 05 ）. Compared with SAP group, the levels of/Icy and hs - CRP were increased in AMI and UAP groups. The level of hs - CRP was posi- tively associated with the level of Hcy （P 〈 0.05 ）. The difference of AMI and UAP groups is not statistically significant. In addition, the sensitivity of single detection of Hcy was 64.12 %, the specificity was 56.46% ; the sensitivity of single detection of hs - CRP was 70.42 %, the specificity was 44.76% ;While the joint detection sensitivity （88.05）and the specificity（80.64） was higher than the single detection. Conclusions Hcy and hs - CRP is the independent risk factors of CHD,the joint detection of Hcy and hs - CRP plays an important role in dignosis of CHD.