Ⅲ～Ⅳ期肺癌患者外周血CIK细胞水平及临床意义研究

目的 :探讨Ⅲ～Ⅳ期肺癌患者外周血CIK细胞水平变化及临床意义。 方法 :流式细胞术检测57例Ⅲ～Ⅳ期肺癌患者及27例健康体检者外周血CIK细胞水平,接受化疗的35例患者治疗后2周再次行外周血CIK细胞水平测定。 结果 :肺癌组外周血CIK细胞水平明显高于正常对照组外周血CIK细胞水平;肺癌组外周血CIK细胞水平与病理类型无关,随临床分期进展而升高;35例接受化疗患者化疗后外周血CIK细胞水平明显低于化疗前。 结论 :Ⅲ～Ⅳ期肺癌患者外周血CIK细胞水平显著升高,有较强抗肿瘤作用;与病理类型无关,受临床分期及治疗干预影响,可作为病情监测的一项指标。

The Level and Clinical Significance of CIK Cells in Peripheral Blood of Patients with Advanced Lung Cancer

Objective :To explore the level of CIK cells in peripheral blood of patients with ad-vanced lung cancer and to analyze its clinical significance. Methods :Flow cytometry was used to de-tect CIK cells in peripheral blood of 57 patients with advanced lung cancer and 27 normal donors. CIKcells in peripheral blood of 35 patients who received 3 cycles of chemotherapy were also measured twoweeks after chemotherapy. Results :The level of CIK cells in peripheral blood of patients with lungcancer was significantly higher than that found in normal donors. There was no relationship between thelevel of CIK cells and pathology, but the CIK cell level increased with TNM stage.The level of CIKcells decreased after chemotherapy. Conclusion :There is an elevated level of CIK cells in patientswith advanced lung cancer. Increased levels of CIK cells might have significant anti-tumor effect.There is no relationship between the level of CIK cells and pathological types, but the CIK cell level isaffected by TNM stage and therapy. CIK cell level may be a useful indicator in the assessment of ad-vanced lung cancer.