| 丙型肝炎病毒感染者血清细胞因子的检测 |
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| 引用本文： | 范学工,刘文思,李聪智. 丙型肝炎病毒感染者血清细胞因子的检测[J]. 中华实验和临床病毒学杂志, 2000, 14(2): 145-147 |
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| 作者姓名： | 范学工 刘文思 李聪智 |
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| 作者单位： | 湖南医科大学湘雅医院传染科,长沙 |
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| 基金项目： | 国家教委优秀年轻教师基金，卫生部优秀青年人才基金资助 |
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| 摘 要： | 目的 探讨丙型肝炎病毒（ＨＣＶ）感染慢性化的宿主免疫机制。方法 用酶联免疫吸附实验测定了１８例慢性ＨＣＶ感染者、１１例正常对照和１０例慢性ＨＢＶ感染者的Ｔ辅助淋巴细胞（Ｔｈ０细胞因子ＩＦＮ－γ，ＩＬ－２，ＩＬ－４和ＩＬ－１０的血清浓度。结果 ＨＣＶ感染者的ＩＬ－２（Ｔｈ１细胞因子）、ＩＬ－４的ＩＬ－１０（Ｔｈ２细胞因子）较正常对照均明显增高（Ｐ〈０．０５，Ｐ〈０．０２５，Ｐ〈０．００１），但以Ｔｈ
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| 关 键 词： | 丙型肝炎病毒 干扰素 细胞因子 宿主免疫 |
| 修稿时间： | 1999-11-24 |
Determination of serum cytokines in individuals with HCV infection |
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| FAN Xuegong,LIU Wenen,LI Congzhi,et al.. Determination of serum cytokines in individuals with HCV infection[J]. Chinese journal of experimental and clinical virology, 2000, 14(2): 145-147 |
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| Authors: | FAN Xuegong LIU Wenen LI Congzhi et al. |
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| Affiliation: | Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To investigate the immunopathogenesis of chronic hepatitis C virus (HCV) infection. METHODS: Serum T-helper lymphocyte (Th1) cytokines (IFN-gamma, IL-2) and Th2 cytokines (IL-4, IL-10) were measured by ELISA in 18 individuals with chronic HCV infection 10 persons of chronic HBV infection and 11 normal persons. RESULTS: IL-2 (P <0.05), IL-4 and IL-10 (P <0.025, P <0.001) were significantly increased in HCV infected hosts as compared to 11 normal controls, the production of Th2 cytokines was more predominant. CONCLUSIONS: An enhanced Th2 responses is present in HCV infection, which may he responsible for the chronicity of HCV infection. |
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| Keywords: | Hepatitis C virus T lymphocyte Interferon Interleukin 2 Interleukin 4 Interleukin 10 |
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