Increase in circulating basement membrane antigens in diabetic rats and effects of insulin treatment |
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| Authors: | J. Risteli K. E. Draeger G. Regitz H. P. Neubauer |
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| Affiliation: | (1) Max-Planck-Institut für Biochemie, Martinsried bei München, FRG;(2) Hoechst AG, Frankfurt am Main, FRG;(3) Present address: Department of Clinical Chemistry, University of Oulu, Finland |
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| Abstract: | Summary The serum concentrations of two recently discovered antigens derived from basement membranes (7-S collagen and laminin P2) were assayed in streptozotocin-diabetic rats as possible indicators of basement membrane metabolism. The concentrations of both increased significantly after 8 weeks of diabetes, and that of 7-S collagen at least remained elevated up to 24 weeks. Treatment with insulin, which did not correct the metabolic disturbances, inhibited the increase in the concentration of 7-S collagen in serum, but did not completely normalize that of laminin P2. |
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| Keywords: | Basement membrane 7-S collagen laminin P2 streptozotocin diabetic rats insulin treatment |
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