| 草酸铂联合氟尿嘧啶、醛氢叶酸治疗晚期结直肠癌的临床观察 |
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Oxaliplatin combined with 5-fluorouracil,leucovorin regimen for patients with advanced colorectal cancer |
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| Suyi Li,Lin Liu,Xiaoyi Gu,Zao Jiang,Cailian Wang. Oxaliplatin combined with 5-fluorouracil,leucovorin regimen for patients with advanced colorectal cancer[J]. The Chinese-German Journal of Clinical Oncology, 2007, 6(3): 225-227 |
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| Authors: | Suyi Li Lin Liu Xiaoyi Gu Zao Jiang Cailian Wang |
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| Affiliation: | Suyi Li(Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University,Nanjing 210009,China)；Lin Liu(Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University,Nanjing 210009,China)；Xiaoyi Gu(Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University,Nanjing 210009,China)；Zao Jiang(Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University,Nanjing 210009,China)；Cailian Wang(Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University,Nanjing 210009,China)； |
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| Abstract: | Objective:To observe the efficacy and tolerability of continuously infusing 5-fluorouracii(5-FU)/folic acid combined with oxaliplatin(L-OHP/5-FU/Lv regimen)as first line treatment in advanced colorectal cancer.Methods:23 patients of advanced colorectal cancer were treated with 5-Fu 500mg/d,civ,d1-d5,d8-d12,leucovorin 100mg/d,iv gtt,d1,d8,folic acid tablet 60 mg/d,po,d2-d5,d9-d12,and oxaliplatin 65mg/(m2-d),iv gtt,d1,d8,repeated every 21 days(one cycle).The effect was evaluated after two cycles.Results:Complete response in 2 cases and partial response in 10 cases were observed with an overall response rate of 47.18%.Adverse effects were mainly grade 1-2,including nausea,vomiting,diarrhea,dental ulcer,peripheral neuritis and myelosuppression.Conclusion:L-OHP/5-FU/LV regimen is an effective and better tolerated alterna tive treatment in advanced colorectal cancer and yields promising clinical application. |
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| Keywords: | advanced colorectal cancer oxaliplatin 5-fluorouracil leucovorin combination chemotherapy |
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