High variability of HLA-B27 alleles in ankylosing spondylitis and related spondyloarthropathies in the population of northern Spain |
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Authors: | Gonzalez Segundo Garcia-Fernandez Sonia Martinez-Borra Jesus Blanco-Gelaz Miguel Angel Rodrigo Luis Sanchez del Río Jose López-Vazquez Antonio Torre-Alonso Juan Carlos López-Larrea Carlos |
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Institution: | Functional Biology Department (S.G.), University of Oviedo, Oviedo, Spain. |
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Abstract: | The distribution of B27 alleles (B*2701-23) was characterized by PCR-SSP in ankylosing spondylitis and related spondyloarthropathies (SpA) in a sample of B27 positive patients from northern Spain. Six B27 alleles were identified: B*2705,02,03,07,08 and B*2713. B*2705 and 02 were the most common alleles in the SpA studied: ankylosing spondylitis (AS) (n = 89), reactive arthritis (ReA) (n = 11), psoriatic arthritis (PsA) (n = 29), and inflammatory bowel disease (IBD) (n = 21). B*2707 and B*2708 were found in PsA patients and B*2703 in one patient with IBD. B*2713 was identified in a healthy control family. B*2713 has not been reported to be represented in either ethnic group. Thus, this population shows higher levels of B27 diversity than other Caucasian groups. |
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