肺癌患者红细胞免疫功能的临床研究

目的：探讨肺癌患者红细胞免疫功能状态以及手术治疗对红细胞免疫功能的影响。方法：对35例经纤支镜检查病理证实为肺癌而未手术的患者以及26例经手术切除病理证实为肺癌的患者行红细胞免疫功能检测，并以30例正常人作对照。结果；手术切除患者与未手术患者相比：前者红细胞C3b受体花环率（RBC C3BRR)、自然肿瘤红细胞花环率（NTER）显著高于后者（P＜0．01），但仍较正常组低（P＜0．05）；而红细胞C3b受体花环促进率（RFER）、直向肿瘤红细胞花环率（DTER）、促肿 瘤红细胞花环率(ETER)及协同肿瘤红细胞花环率（ATER）均高于后者（P＜0．01），且与正常对照无显著差异（P＞0．05）；红细胞免疫复合物 花环率（RBC ICR）低于后者（P＜0．01），且与正常对照无显著差异（P＞0．05）；红细胞C3b受体花环抑制素（RFIR）低于后者（P＜0．01），但仍高于正常对照组（P＜0．01）。结论；肺癌患者手术切除原发肿瘤后，机体红细胞免疫功能可逐渐恢复。机体红细胞免疫功能状态与肿瘤组织负荷有密切关系。

A clinical research on immuno-function of erythrocytes in the patients with pulmonary carcinoma

Objective To study the immuno-function of erythrocytes and the influence of surgical treatment on it in the patients with lung cancer. Methods A total of 61 patients with lung cancer were studied, consisting of 35 non-operative patients and 26 post-operative patients. Their immuno-function of erythrocytes was analyzed and compared with 30 normal controls. Results In the post-operative group, the values of RBC C3BRRT and NTER were significantly higher than those of non-operative group (P<0.01), but still lower than those of normal control group (P<0.05); RFER, DTER, ETER and ATER higher than those of non-operative group (P<0.01), and not significantly different from normal control group (P>0.05); RBC ICR lower than that of non-operative group (P<0.01), and not remarkably different from normal control group (P>0.05); and RFIR lower than that of non-operative group (P<0.01), however, still higher than that of normal control group (P<0.01). Conclusion The immuno-function of erythrocytes may be related to body tumor load of the patients with lung cancer, and it may gradually recover after the primary tumor is resected.