食管鳞癌组织中异常表达蛋白的预后研究进展

食管癌（EC）是我国常见的恶性肿瘤之一，是威胁人民生命健康的重大疾病。以手术为主的综合治疗改善了EC患者术后的生活质量和远期生存．但很多患者会在术后发生复发或转移．预后较差。目前TNM分期是影响EC患者预后最明确也是最重要的因素．此外仍存在着其他影响EC患者预后的因素。对于食管鳞癌（ESCC）中异常表达蛋白的探索可能为完善分期，指导预后提供新的线索。我们回顾了ESCC组织中与预后有关的蛋白质表达异常方面的文献，并试图探讨这些蛋白分子在ESCC中预后价值和潜在的临床应用。

Research progress of prognostic protein biomarkers associated with esophagus squamous cell carcinoma

Esophageal cancer （EC） is one of the common malignant tumors in China. Esophagectomy based on multi-disciplinary principle improves the quality of life and survival of esophageal cancer patients, but a lot of patients will suffer recurrence or metastasis after surgery. TNM stage is the most important factor which affects the prognosis of patients with esophageal cancer. Besides, there are other prognostic factors, such as abnormal expression of the proteins. Exploration of these proteins may provide new clues to improve prognosis in esophageal squamous cell cancer （ESCC）. We reviewed the literatures related to abnormal protein expression in ESCC, and tried to elucidate the prognostic value and potential clinical application of these proteins in ESCC.