| 米非司酮对围绝经期子宫肌瘤患者疗效及子宫内膜的影响 |
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| 引用本文： | 韩冬梅.米非司酮对围绝经期子宫肌瘤患者疗效及子宫内膜的影响[J].内蒙古医学杂志,2007,39(1):48-49. |
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| 作者姓名： | 韩冬梅 |
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| 作者单位： | 包头铁路医院妇产科,内蒙古,包头,014040 |
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| 摘 要： | 目的：观察长期低剂量米非司酮对围绝经期异常出血的子宫肌瘤患者的疗效和对子宫内膜的影响。方法：选择围绝经期有异常出血的子宫肌瘤患者12例，口服米非司酮10mg／d，连续6个月，观察治疗后临床效果、子宫内膜病理的变化。结果：用药期间患者均闭经，治疗后较治疗前血红蛋白平均升高32g／L，子宫肌瘤的最大直径下降显著（P〈0．01）；治疗后子宫内膜病理呈现增生期和（或）分泌期变化，未见异型性。结论：长期低剂量应用米非司酮治疗围绝经期异常出血的子宫肌瘤患者是安全有效的。
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| 关 键 词： | 米非司酮 子宫肌瘤 子宫内膜 |
| 文章编号： | 1004-0951（2007）01-0048-02 |
| 修稿时间： | 2006-10-28 |
The Effects of Mifepristone(RU486) on The Endometrium and Uterine Myoma in Perimenopausal Women |
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| HAN Dong-mei.The Effects of Mifepristone(RU486) on The Endometrium and Uterine Myoma in Perimenopausal Women[J].Inner Mongolia Medical Journal,2007,39(1):48-49. |
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| Authors: | HAN Dong-mei |
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| Institution: | Department of Obstetrics and Gynecology, Baotou Railway Hospital, Baotou 014040 China |
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| Abstract: | objective: To determine the clinical effects and to examine endometrial response to long-term low-dose RU_(486) administration in perimenopausal women with uterine myomas.Methods: 12 perimenopausal paients of uterine myomas with abnormal bleeding were administrated with 10mg RU_(486) daily for 6 months.The clinical response,endometrial morphology were reviewed and analyzed.Results: Amenorrhea occurred in all patients during the period of treatment.Compared with those before treatment,blood hemoglobin increased by 32g/L,and the largest diameter of the myoma decreased significantly(P<0.01).Endometrium appeared as proliferative and/or secretory stage.While no cytologic atypia was seen.Conclusions: Long-term low-dose RU_(486) administration is effective and safe in treating perimenopausal patients with uterine myomas and dysmenorrhea. |
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| Keywords: | Mifepristone Uterine myoma Endometrium |
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