脑肿瘤磁敏感对比MR灌注成像技术方法的研究

研究动态敏感对比MR灌注技术在脑肿瘤研究中的应用技术和某些限制。材料和方法 :使用GEsigna1.5TMR扫描仪对本院20例头颈部疾病患者(未见颅内病变而需增强扫描者)及30例脑肿瘤患者(均经术后病理证实)进行常规平扫加增强MR检查同时使用SEEPI和GEEPI序列进行快速团注造影剂后MR灌注扫描。获得资料经在线工作站后处理分析。结果 :所有病例均获得相应功能图像及信号时间曲线 ,经肘正中静脉注射者45例均获得较为理想的功能图像及时间信号曲线。其余5例经腕表浅静脉及股静脉注射者曲线不完整。1例冠状位成像者图像变形。脂肪抑制预扫描及TR=1800ms ,TE=40ms ,FLIP角=60°的GEEPI序列为脑肿瘤灌注研究较为理想的选择。结论 :正确应用动态敏感对比MR灌注技术对脑部疾病进行定性及半定量研究 ,基本可以满足临床工作的需要

Technological Strategies of the Dynamic Susceptibility Contrast MR Perfusion Imaging in Brain Tumors

Purpose:To study the dynamic susceptibility contrast (DSC)MR perfusion technological strategies in clinical use and its limits.Materials and Methods:Thirty brain tumor patients(10 meningiomas,15 gliomas and 5 brain metastasis tumors) and 20 controls(without intro-skull disease but need enhancement) were undergone DSC MR imaging after a routine MR scanning in a 1.5T clinical MR scanner(GE Medical System,USA).GD-DTPA were used as contrast agent;different doses and injection methods were studied;SE EPI?GE EPI sequences were used in perfusion examinations.After perfusion examination,routine enhanced T1WI MR imaging with exact copy of perfusion slice selection was performed in every patient for image fusion and post-processing.All raw data were sent to and handled with on-line working station afterward.Results:All cases got functional rCBV,rCBF,MTT and TTP images and time-signal curves;45 cases with bolus injection of GD-DTPA in middle elbow vein got ideal function images and curves,no significant statistic difference with different trace doses(10ml and 20ml).The other 5 cases injected in wrist veins and femur vein got irregular curves;1 patient doing coronal perfusion imaging got deformed function images.Fat suppressed GE EPI sequence(TR=1800ms,TE=40ms,FLIP angle=60) is most favorable for brain tumor perfusion studies.Conclusion:Correct use of DSC MR perfusion technological strategies while examining patients with brain tumors can fulfill clinical needs of quality and half-quantity measurements.