Absence of Epstein-Barr virus in esophageal squamous cell carcinoma |
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| Authors: | S. Sunpaweravong W. Mitarnun P. Puttawibul |
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| Affiliation: | Department of Surgery, Songklanagarind Hospital, Prince of Songkla University, Songkla, Thailand. susomkia@medicine.psu.ac.th |
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| Abstract: | It is strongly suspected that the Epstein-Barr virus (EBV) plays a role in the genesis of nasopharyngeal and gastric carcinoma. The aim of this study was to search for such a connection between esophageal squamous cell carcinoma (ESCC) and EBV. We investigated 104 surgically resected esophageal cancers using in situ hybridization (ISH) for EBV-encoded RNA (EBER). We found no EBER-positive cancer cells in any tests, although there were five samples in which EBER-positive tumor-infiltrating lymphocytes (TILs) were found. We conclude from this study that EBV is not associated with ESCC. |
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| Keywords: | Epstein-Barr virus esophageal squamous cell carcinoma etiology |
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