| 四神丸对小鼠结肠炎性病变后诱发结肠癌化学预防作用研究 |
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| 引用本文： | 曹阳,赵丹玉,柴纪严,田振国.四神丸对小鼠结肠炎性病变后诱发结肠癌化学预防作用研究[J].辽宁中医药大学学报,2012(11):127-129. |
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| 作者姓名： | 曹阳 赵丹玉 柴纪严 田振国 |
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| 作者单位： | 辽宁中医药大学;辽宁省肛肠医院 |
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| 摘 要： | 目的：观察四神丸对小鼠结肠炎性病变后诱发结肠癌化学预防作用。方法：40只ICR小鼠,随机分为正常对照组、模型组、四神丸口服给药组和四神丸灌肠给药组4组。以40mg/g 1,2-二甲肼（DMH）腹腔注射、20g/L右旋葡聚糖苷钠（DSS）饮用水诱导小鼠结肠炎性病变后诱发结肠癌模型。口服和灌肠四神丸组分别给予0.2mL四神丸浸膏剂（生药浓度2g/mL）,共21周后,观察小鼠脾脏、胸腺、结肠质量,结肠组织病理变化和四神丸对小鼠结肠炎性病变后诱发结肠癌发生率的影响。结果 ：与模型组相比,四神丸可以明显改善小鼠DMH＋DSS诱癌过程中胸腺等组织的改变和恶病质状态,同时四神丸明显抑制小鼠结肠炎性病变后诱发结肠癌,并降低成癌率。但口服和灌肠两种给药方式对结果没有影响。结论：四神丸能抑制小鼠结肠炎性病变后诱发结肠癌。
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| 关 键 词： | 四神丸 结肠炎 结肠癌 化学预防 |
Chemopreventive Effect of Sishen Pill on Experimental Colon Cancer in Rats |
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| CAO Yang,ZHAO Dan-yu,CHAI Ji-yan,TIAN Zhen-guo.Chemopreventive Effect of Sishen Pill on Experimental Colon Cancer in Rats[J].Journal of Liaoning University of Traditional Chinese Medicine,2012(11):127-129. |
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| Authors: | CAO Yang ZHAO Dan-yu CHAI Ji-yan TIAN Zhen-guo |
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| Institution: | 1.Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;2.Liaoning Coloproctological Hospital,Shenyang 110001,Liaoning,China) |
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| Abstract: | Objective:To investigate the chemopreventive effect of Sishen Pill on experimental colon cancer in rats.Method:Colon cancer model of rats was induced by 1,2 dimethylhydrazine(DMH,40mg/g)and dextran sodium sulfate(DSS,20g/L).All rats were randomly divided into 4 groups:normal group;control group(DMH+DSS);Sishen Pill oral group(DMH+DSS+ Sishen Pill 400mg);Sishen Pill for enema group(DMH+DSS+ Sishen Pill 400mg).The drugs were given once a day.21 weeks later,the weights of spleen,thymus and colon,as well as the morphological changes in rat colon tissues were evaluated.Result:Sishen Pill significantly improved the cachexia induced by DMH+DSS,and also significantly inhibited colon cancer incidence in the rats.Conclusion:Sishen Pill can inhibit colon tumor formation induced by DMH+DSS. |
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| Keywords: | Sishen Pill colonitis colon cancer chemoprevention |
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