| 高效液相色谱法测定急支糖浆中盐酸麻黄碱含量 |
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| 引用本文： | 李永杰,冷爱晶.高效液相色谱法测定急支糖浆中盐酸麻黄碱含量[J].辽宁中医药大学学报,2012(10):200-201. |
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| 作者姓名： | 李永杰 冷爱晶 |
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| 作者单位： | 大连医科大学附属第一医院 |
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| 摘 要： | 目的:采用高效液相色谱(HPLC)法测定急支糖浆盐酸麻黄碱的含量。方法:采用Kromasil C18柱(150mm×4.6mm,5μm),流动相0.05mol/L磷酸二氢钾(用磷酸调节pH=3)-甲醇(80:20),流速为1mL/min,检测波长210nm;柱温室温。结果:盐酸麻黄碱质量浓度的线性范围为25～75μg/mL,r=0.9993,平均回收率为97.53%,RSD=0.92%。结论:HPLC法简便、快速、灵敏度高,可用于测定盐酸麻黄碱含量,进行控制药品质量。
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| 关 键 词： | 急支糖浆 高效液相色谱法 盐酸麻黄碱 含量测定 |
LC Determination of Ephedrine Hydrochloride in Jizhi Syrup |
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| LI Yong-jie,LENG Ai-jing.LC Determination of Ephedrine Hydrochloride in Jizhi Syrup[J].Journal of Liaoning University of Traditional Chinese Medicine,2012(10):200-201. |
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| Authors: | LI Yong-jie LENG Ai-jing |
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| Institution: | (First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning,China) |
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| Abstract: | Objective:The purpose is to determine the contents of ephedrine hydrochloride in Jizhi syrup using high performance liquid chromatography(HPLC).Method:Kromasil C18 column(150mm×4.6mm,5μm) is used with 0.05mol/L potassium dihydrogen phosphate(adjusted with orthophosphoric acid,pH=3)-methanol(80:20);flow rate:1mL/min;detection wavelength:210nm;column temperature:ambient temperature.Result:Linear range of ephedrine hydrochloride is 25～75μg/mL,r=0.9993,mean recovery is 97.53%,RSD=0.92%.Conclusion:The simple,rapid and high sensitive HPLC method can be used to determine the contents of ephedrine hydrochloride and to control the quality. |
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| Keywords: | Jizhi syrup HPLC ephedrine hydrochloride content determination |
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