| 抗纤灵冲剂对5/6肾切除大鼠尿微量蛋白干预作用 |
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| 引用本文： | 张长明,顾耀东,何立群. 抗纤灵冲剂对5/6肾切除大鼠尿微量蛋白干预作用[J]. 辽宁中医药大学学报, 2012, 0(9): 52-54 |
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| 作者姓名： | 张长明 顾耀东 何立群 |
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| 作者单位： | 上海中医药大学附属市中医医院肾内科;上海中医药大学附属曙光医院肾内科 |
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| 基金项目： | 上海市卫生局科研课题项目(2010220);上海市高校博士学科点专项科研基金资助项目(20093107110006);上海市教委高校创新团队科研课题项目(201106) |
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| 摘 要： | 目的:探讨5/6肾切除大鼠尿微量蛋白的改变以及抗纤灵冲剂干预作用。方法:将40只SD大鼠中30只行5/6肾切除,造模成功后分为正常组、模型组、抗纤灵组、氯沙坦组。药物干预12周后分批处死,留取血液及24小时尿液,检测肾功能(尿素氮、肌酐)以及尿转铁蛋白(TRF)、α1微球蛋白(α1-MG)、β2微球蛋白(β2-MG)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)以及24小时尿蛋白定量。结果:抗纤灵组及氯沙坦组较模型组肌酐、尿素氮有所下降,降低α1-MG、β2-MG、NAG、TRF。结论:抗纤灵冲剂可明显改善5/6肾切除大鼠的肾功能,在降低尿微量蛋白方面与氯沙坦等效,可能是抗纤灵冲剂通过改善肾小球通透性,加强肾小管的重吸收来降低各种蛋白尿。
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| 关 键 词： | 5/6肾切除模型 尿微量蛋白 肾功能 抗纤灵冲剂 |
Effect of Kangxianling Medicinal Granules on Urine Small Protein in Rats with 5/6 Nephrectomy |
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| ZHANG Chang-ming,GU Yao-dong,HE Li-qun. Effect of Kangxianling Medicinal Granules on Urine Small Protein in Rats with 5/6 Nephrectomy[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2012, 0(9): 52-54 |
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| Authors: | ZHANG Chang-ming GU Yao-dong HE Li-qun |
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| Affiliation: | 1.Kidney Department,Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;2.Kidney Department,Shanghai Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China) |
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| Abstract: | Objective:To study change of urine small protein in rats with 5/6 nephrectomy and effect of Kangxianling medicinal granules on it.Methods:SD rats(n=40)were experienced 5/6 nephrectomy,and then randomized into four groups,one with Kangxianling medicinal granules(n=10),one with Cozaar(n=10),one without medicine(n=10),one without 5/6 nephrectomy and medicine(n=10).12 weeks later,urea nitrogen,creatinine,transferring(TRF),α1 microglobulin(α1-MG),β2 microglobulin(β2-MG),N-acetyl-β-D-glucosaminidase(NAG)and 24h urine protein quantitation were tested.Results:The levels of urea nitrogen and creatinine in blood and the levels of α1-MG,β2-MG,NAG and TRF in urine were decreased in group with Kangxianling medicinal granules and group with Cozaar compared with group with 5/6 nephrectomy without medicine(P<0.05).Conclusion:Kangxianling medicinal granules could evidently improve renal function and decrease urine small protein in rats with 5/6 nephrectomy,which may be by improving glomerular permeability and enhancing renal tubule reabsorption. |
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| Keywords: | 5/6 nephrectomy model urine small protein renal function Kangxianling medicinal granules |
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