| 氨基葡萄糖对小鼠免疫功能的影响 |
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| 引用本文： | 付辰炜,刘万顺,韩宝芹,杨艳,刘冰.氨基葡萄糖对小鼠免疫功能的影响[J].营养学报,2007,29(1):51-53,57. |
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| 作者姓名： | 付辰炜 刘万顺 韩宝芹 杨艳 刘冰 |
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| 作者单位： | 中国海洋大学海洋生命学院,青岛,266003 |
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| 摘 要： | 目的:研究氨基葡萄糖(GlcNH2)对小鼠免疫功能的影响。方法:用体外实验方法测定GlcNH2对小鼠脾淋巴细胞增殖能力的影响;进一步研究GlcNH2在体内促进免疫功能的作用,给小鼠灌服GlcNH2后,对其免疫功能指标进行测定,主要包括单核巨噬细胞吞噬功能,绵羊红细胞所致小鼠迟发型超敏反应,小鼠抗体生成能力(以半数溶血值表示),以及小鼠免疫器官指数(脾脏和胸腺)。结果:GlcNH2在体外能显著促进小鼠脾淋巴细胞增殖,体内研究结果表明GlcNH2能够提高单核巨噬细胞的吞噬功能,增强迟发性超敏反应,提高小鼠抗体生成能力,并增加脾脏和胸腺指数。结论:GlcNH2对特异性细胞免疫功能和体液免疫功能以及非特异性免疫功能均有明显的促进作用,能够增强小鼠免疫功能。
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| 关 键 词： | 氨基葡萄糖 细胞免疫 体液免疫 非特异性免疫 |
| 文章编号： | 0512-7955（2007）01-0051-04 |
| 修稿时间： | 2006-06-20 |
EFFECTS OF GLUCOSAMINE ON IMMUNE FUNCTION IN MICE |
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| FU Chen-wei,LIU Wan-shun,HAN Bao-qin,YANG Yan,LIU Bing.EFFECTS OF GLUCOSAMINE ON IMMUNE FUNCTION IN MICE[J].Acta Nutrimenta Sinica,2007,29(1):51-53,57. |
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| Authors: | FU Chen-wei LIU Wan-shun HAN Bao-qin YANG Yan LIU Bing |
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| Institution: | The Department of Marine Biology Life, Ocean University of China, Qingdao 266003, China |
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| Abstract: | Objective:To study the effects of glucosamine(GlcNH2) on immune function in mice.Method:The effects of GlcNH2 on murine proliferation of splenocytes were carried out in vitro.After feeding mice by GlcNH2,the phagocytotic functions of mononuclear macrophage,murine delayed type hypersensitivity(DTH) caused by sheep red blood cells(SRBC),the ability of antibody production(tested by HC50),and the index of immune organs(thymus and spleen) were deteimined in vivo.Results:GlcNH2 could promote the proliferation of splenocytes,phagocytotic functions of mononuclear macrophage,DTH,the ability of antibody production and the index of immune organs.Conclusion:Glucosamine can enhance immune function in mice such as cellular immunity,humoral immunity and non-specific immunity. |
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| Keywords: | glucosamine cellular immunity humoral immunity non-specific immunity |
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