溶质转运蛋白(SLC)与皮肤病

溶质转运蛋白是细胞内数量较大的一类转运蛋白,能够转运核酸、氨基酸、糖类、离子、矿物质、药物等各种物质,是调节和控制细胞内外物质转运的重要通道。近年来,越来越多的研究发现SLC家族成员在多种皮肤疾病的发病过程中起到重要作用,如麻风、系统性红斑狼疮、银屑病及皮肤肿瘤等等。本文就近年来关于溶质转运蛋白家族在皮肤疾病中的研究给予总结和概述。

The Human Solute Carriers and Dermatosis

The solute carriers(SLC)are transmembrane proteins,playing a crucial role in regulating substances in and out of cells,including nucleotides,amino acids,sugars,ions,minerals,dmgs,etc.Recently,more and more studies demonstrated that SLC family members play important pathogenic role in the development of various skin diseases,including leprosy,SLE,psoriasis and cutaneous tumors.In this review,results of recent studies in dermatoses associated with SLC has been summarized.