接枝肝素血导管用于动物实验的结果分析

我们口径仅0.6mm、内壁接枝肝素的血导管，经14只大白鼠的尾动脉侧血压试验与股动静脉搭桥对照实验，结果显示，同一根接枝管在各只鼠尾动脉重复使用仍抗凝血，切口处不渗血，内腔也不会大出血。整个实验中不需外加抗凝剂。用粗细不匀的接枝肝素血管导管，经4只兔、4条狗的股动脉测血压与股动静脉搭桥对照实验发现，虽然内壁接枝肝素血导管的抗凝血效果显著改善，但管内仍有血栓条形成。而管壁却无血栓痕迹。血栓条从粗细交叉锥形处首先形成。实验结果表明，因为血流阻力与血导管半径的4次幂成反比。血导管超细，则血流阻力对血导管半径的变化越敏感。所以研制人工血导管时，其口径应对血管口径一致。

Analyses of the Results of an Animal Experiment on Graft-Heparin Conduits

We inserted the 0.6 mm caliber graft heparin (in inner wall)conduits into the tailarteries of 14 mice. The results showed that the graft conduit could be used repeatedly with no blood oozing out in the wound, no massive internal hemorrrhage, and no additional coagulative reagent given during the whole experiment. On the other hand, the graft heparin conduits of variant caliber were inserted into the femur arteries of 4 rabbits and 4 dogs for blood pressure experiment and femur arterio venous bypass tests. The results showed that the anticoagulative effect of these conduits was markedly improved, but there was a strip of thrombus. There was no thrombus track in the wall of the conduit. The strip of thrombus was formed first in the cone of conduit where caliber changed. The results indicate that the blood flow resistance is in inverse proportion to 4 power of the conduit radius. So the thinner the conduit is, the more sensitive to conduit radius variation the conduit resistance will be. In studying and making the arfificial conduit, one must take notice of the conduit caliber, which should be equal to the caliber of the blood vessel.