雌雄FMMU白化豚鼠基础生理生化指标的差异分析

目的 测定与比较雌、雄普通级FMMU白化豚鼠血液指标、心率、颈总动脉压及心室压、脏器参数。方法 取250~350 g普通级FMMU白化豚鼠30只,雌雄各半,饲养一周后,心脏采血测定血液生理生化及血气指标;颈总动脉插管测定动脉压,呼吸支持情况下开胸进行心室压测定;解剖并精确称量各脏器重量。结果 雄性与雌性豚鼠比较:血液指标中,血小板计数、谷丙转氨酶、总胆红素、乳酸的差异有显著性意义(P<0.05或P<0.01);颈总动脉舒张压、平均压以及左心室收缩压、平均压的差异有显著性意义(P<0.05或P<0.01);各主要的脏器重量及脏器系数均无显著性差异。结论 普通级雌雄FMMU白化豚鼠血液生理生化、血气及心血管功能指标存在差异。

The measurement and comparison of basic physiological and biochemical index of male and female FMMU albimo guinea-pig

Objective To determine and compare the parameters of blood, heart rate, carotid artery pressure, ventricular pressure and organ indexes of male and female FMMU albino guinea-pig.Methods A total of 30 guinea-pig about 250~350 g weight were fed for a week, then blood physiological and biochemical index, blood gas and carotid artery pressure were determined, ventricular pressure were measured by arterial catheterization and heart rate were measured on the respiratory support condition. Finally,weight of guinea-pig body and main organ were weighed. Result The difference of platelet count, glutamic-pyruvic transaminase,total bilirubin and lactic acid were significant(P<0.05 or P<0.01). The difference of carotid diastolic blood pressure and mean blood pressure, left ventricular systolic pressure and mean pressure were totally significant(P<0.05 or P<0.01). And there were no significant differences in weight and organ coefficient of main organs. Conclusion There were differences in blood physiology and biochemistry, blood gas, carotid artery pressure and ventricular pressure in different gender of the ordinary grade FMMU albino guinea-pig.