| 颌面部爆炸伤后组织血栓素A2和前列环素I2对兔脑的作用机制 |
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| 引用本文： | 刘瑞峰,刘彦普,周树夏,何黎升,王翔,马全利.颌面部爆炸伤后组织血栓素A2和前列环素I2对兔脑的作用机制[J].中国组织工程研究与临床康复,2002,6(11):1705-1706. |
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| 作者姓名： | 刘瑞峰 刘彦普 周树夏 何黎升 王翔 马全利 |
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| 作者单位： | LIURui-fengStomatologyCollegeFourthMilitaryMedicalUniversity，Xi'an710032，ChinaLIUYan-puStomatologyCollegeFourthMilitaryMedicalUniversity，Xi'an710032，ChinaZHOUShu-xiaStomatologyCollegeFourthMilitaryMedicalUniversity，Xi'an710032，ChinaHELi-shengStomatologyCo |
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| 摘 要： | Blastinjuryofneckandheadisamainwoundtypeinaccident，violenceandwarwound．Andtheskullwillbeimpactednecessarilyduringthosecourses．thromboxaneA２（TXA２）canincreaseresistingforceofcerebralbloodcirculationandprostacyclinI２（PGI２）canpre－ventthebrainviadilatingvessels犤１－２〗．ThehalflifeofTXA２andPGI２isshortinblood，andnoteasytodetectdirectly．Usuallydetectthestablenon－activityproduction－TXB２and６－ketop－PGF１αtorepresentTXA２andPGI２．HereweinvestigatethechangeofTXA２andP…
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Investigation on mechanism of action of tissue TXA2 and PGI2 on rabbits' brains after maxillofacial explosive injury |
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| LIURui-fengStomatologyCollegeFourthMilitaryMedicalUniversity,Xi'an,ChinaLIUYan-puStomatologyCollegeFourthMilitaryMedicalUniversity,Xi'an,ChinaZHOUShu-xiaStomatologyCollegeFourthMilitaryMedicalUniversity,Xi'an,ChinaHELi-shengStomatologyCo.Investigation on mechanism of action of tissue TXA2 and PGI2 on rabbits'' brains after maxillofacial explosive injury[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2002,6(11):1705-1706. |
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| Authors: | LIURui-fengStomatologyCollegeFourthMilitaryMedicalUniversity Xi'an ChinaLIUYan-puStomatologyCollegeFourthMilitaryMedicalUniversity Xi'an ChinaZHOUShu-xiaStomatologyCollegeFourthMilitaryMedicalUniversity Xi'an ChinaHELi-shengStomatologyCo |
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| Institution: | 1. Stomatology College,Fourth Military Medical University,Xi'an 710032,China
2. Second Hospital in Mudanjiang,Mudanjiang 154000,China |
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| Abstract: | Objective To detect the changes of TXA2 and PGI2 levels and discuss the significance of the level and ratio changes during maxillofacial blast injury.Methods The maxillofacial blast injury model was made by standard spherical blast sources produced by NINT.Measure dynamics of blast wave to skin surface.The metabolites of thromboxane A2( TXA2) and prostacyclin(PGI2),TXB2 and 6 keto PGF1α ,in cortex were examined before and 10min,6h,12h,24h,72h,168h after injury by radioimmunoassay.Results The pressure of central skin of blast injury was 335MPa.TXB2 and 6 keto PGF1 levels and the ratio augmented gradually after injury,and reached the peaks (216.8± 22.5)pg/g and (102.9± 13.5)pg/g respectively] at the 24th hour,and reduced to the normal levels at the 7th day.Conclusions The blast wave can injure the cortex and vessels,thus TXA2 and PGI2 levels and the ratio increase, which aggravate injury of the cerebral cortex. |
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| Keywords: | blast injury thromboxane A2(TXA2) prostacyclin I2(PGI2) radioimmunoassay |
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