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| pH敏感含糖三元共聚水凝胶Poly(AM-CO-IA-VBG)的药物释放性能研究 | |
| 引用本文： | 席延卫,李凌冰,谭业邦,胥振芹,李英.pH敏感含糖三元共聚水凝胶Poly(AM-CO-IA-VBG)的药物释放性能研究[J].生物医学工程学杂志,2007,24(3):603-606. |
| 作者姓名： | 席延卫 李凌冰 谭业邦 胥振芹 李英 |
| 作者单位： | 1. 山东大学,药学院,药物药剂所,济南,250012 2. 山东大学,化学与化工学院,济南,250100 3. 山东省日照市东港区人民医院,日照,276800 |
| 基金项目： | 国家自然科学基金;山东大学预研基金 |
| 摘 要： | 用4-乙烯基苄基胺与葡萄糖内酯反应合成了4-乙烯苄基葡萄糖酰胺单体(VBG)。以亚甲基双丙烯酰胺(BisA)为交联剂,用过硫酸钾(KPS)引发丙烯酰胺(AM)、衣康酸(IA)及4-乙烯苄基葡萄糖酰胺使之共聚,得到pH敏感含糖结构的三元共聚水凝胶。用核磁共振及红外光谱对单体和水凝胶的结构进行了表征,研究了不同水凝胶中药物的释放性能,以及pH值及盐的浓度对水凝胶中药物释放的影响。结果表明:水凝胶中药物在低pH值时或盐中药物释放显著下降,表明水凝胶对酸或盐有强烈的响应性。 |
| 关 键 词： | pH敏感 水凝胶 含糖 释药特性 |
| 修稿时间： | 2005-04-042005-07-14 |
The Drug Release Properties of Poly(acrylamide-co- itaconate-vinylbenzylglycosylallylamide) Hydrogels |
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| Xi Yanwei,Li Lingbing,Tan Yebang,Xu Zhenqin,Li Ying.The Drug Release Properties of Poly(acrylamide-co- itaconate-vinylbenzylglycosylallylamide) Hydrogels[J].Journal of Biomedical Engineering,2007,24(3):603-606. | |
| Authors: | Xi Yanwei Li Lingbing Tan Yebang Xu Zhenqin Li Ying |
| Institution: | Department of Pharmacy, Shandong University, Ji'nan 250012, China. |
| Abstract: | Sugar-containing monomer vinylbenzylglycosylallyamide (VBG) was synthesized by vinylbenzyl amine and delta-gluconolactone in dimethylformamide(DMF) solution. The sugar-based hydrogel was prepared by free radical crosslinking copolymerization of VBG, itaconic acid (IA) and acrylamide (AM). The release properties of Aspirin from xerogels matrices and from hydrogel in different pH solutions and different concentration NaCl solutions were studied respectively. The release mechanism of Aspirin was further confirmed by evaluating the n value in Peppas equation. The results indicated that the drug release increased with the increase of pH values and with the decrease of NaCl concentration. |
| Keywords: | pH-sensitive Hydrogel Sugar-based Drug release properties |
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