The effect of separate red blood cells on capillary tissue oxygenation calculated with a numerical model |
| |
Authors: | BOS, CEES HOOFD, LOUIS OOSTENDORP, THOM |
| |
Affiliation: | Department of Physiology, University of Nijmegen PO Box 9101, 6500 HB Nijmegen, The Netherlands Department of Medical Physics and Biophysics, University of Nijmegen PO Box 9101, 6500 HB Nijmegen, The Netherlands |
| |
Abstract: | Author to whom correspondence should be addressed In simplified models that describe large quantities of capillariesthe capillary content is considered to be homogeneous for oxygentransport; but, in reality, the capillaries contain discretered blood cells (RBCs), and this discreteness will affect oxygentransport from the capillary to the tissue. This was previouslyinvestigated with an analytical model, where RBCs were modelledas point-like sources. A numerical approach is used in thisinvestigation, and the results are compared with the analyticalmodel. In both models the effect of the particulate nature ofblood depends on the haematocrit and on the RBC velocity. Thereis only a minor difference between the two models. For rat hearts,the correction factor used in this study, the extraction pressure,can be up to 3 kPa (23 mmHg). |
| |
Keywords: | tissue oxygenation mathematical model particulate nature capillaries microcirculation rat heart |
本文献已被 Oxford 等数据库收录! |
|