Pharmacokinetics of darbepoetin alfa after intravenous or subcutaneous administration in patients with non-myeloid malignancies undergoing chemotherapy |
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| Authors: | Heatherington Anne C Dittrich Christian Sullivan John T Rossi Greg Schueller Johannes |
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| Affiliation: | Amgen Inc., Thousand Oaks, California, USA. |
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| Abstract: | BACKGROUND AND OBJECTIVE: The pharmacokinetics of darbepoetin alfa after intravenous (IV) administration in the oncology setting have not been previously reported. The objective of this study was to evaluate the pharmacokinetics of IV or subcutaneous (SC) darbepoetin alfa in patients with non-myeloid malignancies undergoing multicycle chemotherapy. METHODS: Fifty-six patients (haemoglobin
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