| 急慢性淋巴细胞白血病免疫表型分析 |
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| 引用本文： | 高原,刘家应,倪麟,陈松立. 急慢性淋巴细胞白血病免疫表型分析[J]. 中国实验诊断学, 2003, 7(5): 386-388 |
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| 作者姓名： | 高原 刘家应 倪麟 陈松立 |
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| 作者单位： | 1. 上海市儿童医院检验科,上海,200040
2. 上海市第二医科大学附属瑞金医院,检验系 |
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| 摘 要： | 目的 探讨急性淋巴细胞白血病(ALL)和慢性淋巴细胞白血病(CLL)细胞免疫表型差异。方法 应用ABCAP免疫组织化学方法，选用一系列的淋巴细胞相关抗原的单抗对169例初发ALL与38例CLL患者进行淋巴细胞表面抗原检测。结果 B-ALL患者白血病细胞的CDl9、HLA-DR阳性率较高，T-ALL患者的白血病细胞以CD7、CD5与CD3阳性率较高，CLL患者的白血病细胞除了以CDl9、CD20、CD22阳性率较高外，CD5也有明显表达。结论 对淋巴细胞白血病患者进行免疫表型分析，对于区别细胞类型，鉴别诊断有重要意义，为临床治疗提供依据。
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| 关 键 词： | 急性淋巴细胞白血病 慢性淋巴细胞白血病 免疫表型 抗原 免疫组织化学 |
| 文章编号： | 1007-4287(2003)05-0386-03 |
| 修稿时间： | 2002-11-18 |
Analysis of the immunophenotype of lymphocytic leukemia |
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| GAO Yuan,LIU Jia-ying,NI Lin,et al.. Analysis of the immunophenotype of lymphocytic leukemia[J]. Chinese Journal of Laboratory Diagnosis, 2003, 7(5): 386-388 |
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| Authors: | GAO Yuan LIU Jia-ying NI Lin et al. |
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| Abstract: | Objective To study the difference in expressing the immunophenotype of acute lymphocytic leukemia(ALL) and chronic lymphocytic leukemia(CLL).Methods The immunophenotypes of 169 ALL cases and 38 CLL cases were determined by a panel of monoclonal antibodies with avidin-biotin-immunoalkaline-phosphatase(ABC-AP) method. Results CD 19 , HLA-DR were highly expressed in B-ALL while CD 7,CD 5 and CD 3 were highly expressed in T-ALL.In CLL,the expression of CD 5 was higher than that of CD 19 ,CD 20 and CD 22 . Conclusion The immunotyping technique is very effective in diagnosing lymphocytic leukemia and may be help for therapy. |
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| Keywords: | acute lymphocytic leukemia chronic lymphocytic leukemia immunophenotype |
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