内皮祖细胞在治疗下肢缺血性疾病中的研究进展

随着人口老龄化、饮食结构改变及引起血管疾病高危因素的增加,下肢缺血性疾病已成为老年人的多发病,是截肢致残的主要原因.作为21世纪最先进的技术,干细胞移植快速地应用于临床,并被认为可能是根治性治疗下肢缺血性疾病的方法之一,内皮祖细胞由于其独特的生物学特性逐渐成为治疗这一病变的新方向和新研究热点.本文着重介绍内皮祖细胞治疗肢体缺血性病变的理论基础和研究进展.

Endothelial progenitor cells in the treatment of lower extremity ischemic disease

With the population aging, diet changing and incveasing risk factors on vascular disease, the lower extremity ischemic disease has become a frequently occurring disease of older person, and it is the main reason for amputation disability. In the 21st century the stem cells transplantation is one of the most advanced technologies and has been applied quickly to clinical therapy, regarded as a radical treatment of lower extremity ischemic disease. Endothelial progenitor cells have gradually become a new direction and a new research focus because of its unique biological characteristics in the treatment of this disease. This article focuses on endothelial progenitor cells in treating extremity ischemia lesions on the theoretical basis and research developments.