| Mechanisms of Depressor Effect of Norepinephrine Injected into Subnucleus Commissuriu of Nucleus Solitarius Tractus in Rabbits |
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| 引用本文： | 张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳. Mechanisms of Depressor Effect of Norepinephrine Injected into Subnucleus Commissuriu of Nucleus Solitarius Tractus in Rabbits[J]. 华中科技大学学报(医学英德文版), 2005, 25(3): 263-264. DOI: 10.1007/BF02828137 |
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| 作者姓名： | 张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳 |
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| 作者单位： | [1]DepartmentofPhysiology,SchoolofBasicMedicalSciences,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China [2]DepartmentofInternalMedicine,andClinic,WuhanTraditionalChineseMedicalHospital,Wuhan430005,China |
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| 摘 要： | This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE)was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. These results suggest that microinjection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of peripheral sympathetic nervous system.
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| 关 键 词： | 病理机制 抑制作用 去甲肾上腺素 交感神经 外周血 |
| 收稿时间： | 2005-04-21 |
Mechanisms of depressor effect of norepinephrine injected into subnucleus commissuriu of nucleus solitarius tractus in rabbits |
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| Zhang Yi,Luo Hongyan,Liu Shenghong,Yi Zhengrong,Li Ai,Hu Xinwd,Liu Changjin,Tang Ming,Liu Lieju,Song Yuanlong,Gao Linlin. Mechanisms of depressor effect of norepinephrine injected into subnucleus commissuriu of nucleus solitarius tractus in rabbits[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2005, 25(3): 263-264. DOI: 10.1007/BF02828137 |
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| Authors: | Zhang Yi Luo Hongyan Liu Shenghong Yi Zhengrong Li Ai Hu Xinwd Liu Changjin Tang Ming Liu Lieju Song Yuanlong Gao Linlin |
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| Affiliation: | 1. Department of Physiology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Department of Internal Medicine, and Clinic, Wuhan Traditional Chinese Medical Hospital, Wuhan 430005, China |
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| Abstract: | This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE) was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. These results suggest that microinjection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of peripheral sympathetic nervous system. |
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| Keywords: | subnucleus commissurius of nucleus solitarius tractus norepinephrine arterial pressure renal nerve discharge |
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