| 甘露聚糖结合凝集素缺损与自身免疫性疾病 |
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| 引用本文： | 刘俐,陈政良. 甘露聚糖结合凝集素缺损与自身免疫性疾病[J]. 免疫学杂志, 2004, 20(Z1): 18-20 |
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| 作者姓名： | 刘俐 陈政良 |
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| 作者单位： | 第一军医大学免疫学教研室,广东,广州,510515 |
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| 基金项目： | 广东省自然科学基金研究团队资助项目(015003) |
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| 摘 要： | 甘露聚糖结合凝集素(MBL)系胶原凝集素家族成员,是天然免疫系统中的重要分子。血清MBL浓度受其结构基因第一外显子几个点突变的影响和启动子区多态性的调控。MBL基因突变使其血清浓度降低,除导致调理吞噬缺损外,还与自身免疫性疾病如系统性红斑狼疮、类风湿性关节炎、干燥综合征、皮肌炎、克隆病、动脉炎等有关。
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| 关 键 词： | 甘露聚糖结合凝集素 天然免疫 免疫缺损 自身免疫病 |
| 文章编号： | 1000-8861(2004)03(S)-0018-03 |
| 修稿时间： | 2004-04-26 |
Relationship between autoimmune disorders and deficiency of mannan-binding lectin |
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| LIU Li,CHEN Zheng-liang. Relationship between autoimmune disorders and deficiency of mannan-binding lectin[J]. Immunological Journal, 2004, 20(Z1): 18-20 |
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| Authors: | LIU Li CHEN Zheng-liang |
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| Abstract: | Mannan-binding lectin is a member of collectin family and plays an important role in innate immune defense. Serum levels of MBL are influenced by three point mutations in exon 1 and further modulated by the polymorphisms in the promoter region of MBL gene. The low serum MBL level is associated with autoimmune disorders, including systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, ermatomyositis, Crohn's disease, IgA glomerulonephritis, giant cell arteritis, and so on. |
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| Keywords: | nnan-binding lectin Innate immunity Immune deficiency Autoimmune disorders |
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