慢性阻塞性肺疾病骨骼肌功能障碍

慢性阻塞性肺疾病(COPD)患者普遍存在骨骼肌功能障碍,表现为骨骼肌耐力和肌力的下降,对运动的易疲劳性。它既可以由骨骼肌萎缩引起,也可以是肌肉氧化能力下降引起的功能性改变。其具体机制目前仍有争论,但越来越多的证据表明COPD患者普遍存在的系统性炎症可能扮演着重要的作用,它通过增加肌肉蛋白降解、减少肌肉蛋白合成修复、促进肌细胞凋亡、抑制肌细胞再生影响骨骼肌容积变化;还可通过抑制过氧化物酶体增殖物激活受体,激活氧化应激等途径改变骨骼肌氧化能力。本文介绍COPD骨骼肌功能障碍的表现和系统性炎症在其中的作用。

Skeletal Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

It has been increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease(COPD).Both strength and endurance of muscles are decreased,and fatigability is increased.Skeletal muscle dysfunction is not only related to muscle wasting,but also to its reduced oxidative capacity.The exact mechanisms have not been elucidated.But more and more evidence has suggested systemic inflammation,which is commonly observed in COPD,might be a potential mechanism in CO...