大肠杆菌Nissle 1917与肠屏障功能的研究进展

革兰氏阴性菌大肠杆菌Nissle 1917(Escherichia coli Nissle 1917,EcN)是一种非乳酸类益生菌。研究发现,EcN能长期稳定定殖于肠道,与肠上皮细胞及肠道其它微生物相互作用,发挥生物学效应。肠道屏障功能是维持肠道正常生理的重要机制,屏障功能的受损与多种疾病相关,寻求对肠道屏障功能有维持和修复作用的物质,是治疗诸多相关疾病的重点突破口。既往的研究发现,EcN对屏障功能有一定的保护作用,本文将从EcN对肠屏障功能的保护作用的产生机制方面进行系统文献综述。

Research advances in Escherichia coli Nissle 1917 and intestinal barrier function

Gram-negative bacteria Escherichia coli Nissle 1917 (EcN) is a non-lactobacillus probiotic. It has long been recognized that EcN could colonize in the intestinal tract and has important biological functions through interacting with intestinal epithelial cells and other enteric microorganisms. Intestinal barriers play a key role in maintaining the homeostasis and physiological functions of the intestinal tract, and the impairment of the barrier function is closely associated with the pathogenesis and development of a variety of diseases. Discovery of some probiotic bacteria that could maintain and repair intestinal barrier function is therefore of critical importance, contributing to develop novel strategies for prevention and treatment of some related diseases. Previous studies have demonstrated that EcN has profoundly protective effects on the intestinal barriers. Here, we systematically reviewed the recent progress on the protective roles of EcN playing in the intestinal barriers and the potential mechanisms.