卵巢癌患者手术前后血清P-selectin、CEA、CA125和TSGF检测的临床意义

目的:探讨了卵巢癌患者手术前后血清可溶性P选择素(P-selectin)、CEA、CA125和TSGF水平的变化及临床意义.方法:分别应用放免法和酶免法、化学法对33例卵巢癌患者进行了血清P-selectin、CEA、CA125和TSGF检测,并与35名正常健康人作比较.结果:手术前卵巢癌患者血清P-selectin、CEA、CA125和TSGF水平均非常显著地高于正常人组(P＜0.01),手术治疗后一年复发组又非常明显地高于未复发组(P＜0.01).结论:测定卵巢癌患者血清中P-selectin、CEA、CA125和TSGF水平的变化与卵巢癌患者的病情和预后密切相关,均具有重要的临床价值.

Clinical Significance of Determination of Changes of Serum P-selectin, CEA, CA125 and TSGF Levels After Operation in Patients with Ovarian Cancer

Objective To study the clinical significance of postoperative changes of serum p-selectin,CEA,CA125 and TSGF levels in patients with ovarian cancer.Methods Serum CEA,CA125(with RIA) P-selectin(with ELISA) and TSGF(with biochemistry) levels were determined in 33 patients with ovarian cancer both before and after operation as well as in 35 controls.Results Before operation,the serum P-selectin,CEA,CA125 and TSGF levels were significantly higher in the patients than those in controls(P<0.01).Twenty-two of the 30 patients underwent operative therapy showed no sign of recurrence at one year and their serum P-selectin,CEA,CA125 and TSGF levels dropped to within normal range.However in the 8 patients with recurrence,the serum levels of P-selectin,CEA CA125 and TSGF remained abnormally high(vs controls,P<0.01).Conclusion Serum P-selectin,CEA,CA125 and TSGF levels were closely related to the diseases process of ovarian cancer and were of prognostic values.