Influenza A/H1N1 2009 pneumonia in kidney transplant recipients: characteristics and outcomes following high‐dose oseltamivir exposure |
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| Authors: | SP Watcharananan T Suwatanapongched P Wacharawanichkul W Chantratitaya V Mavichak SB Mossad |
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| Institution: | 1. Department of Infectious Disease;2. Radiology Department, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;3. Institute of Kidney Transplantation, Praram 9 Hospital, Bangkok, Thailand;4. Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;5. Department of Infectious Disease and Transplantation Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA |
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| Abstract: | S.P. Watcharananan, T. Suwatanapongched, P. Wacharawanichkul, W. Chantratitaya, V. Mavichak, S.B. Mossad. Influenza A/H1N1 2009 pneumonia in kidney transplant recipients: characteristics and outcomes following high‐dose oseltamivir exposure.Transpl Infect Dis 2010: 12: 127–131. All rights reserved Abstract: We report 2 cases of severe pneumonia due to the novel pandemic influenza A/H1N1 2009 in kidney transplant recipients. Our patients initially experienced influenza‐like illness that rapidly progressed to severe pneumonia within 48 h. The patients became hypoxic and required non‐invasive ventilation. The novel influenza A/H1N1 2009 was identified from their nasal swabs. These cases were treated successfully with a relatively high dose of oseltamivir, adjusted for their renal function. Clinical improvement was documented only after a week of antiviral therapy. Despite early antiviral treatment, we showed that morbidity following novel pandemic influenza A/H1N1 2009 infection is high among kidney transplant recipients. |
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| Keywords: | influenza A H1N1 oseltamivir pneumonia kidney transplant |
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