Twenty four‐hour ambulatory blood pressure profiles 12 months post living kidney donation

Small blood pressure (BP) elevations may occur post kidney donation. This prospective study determined 24‐h ambulatory BP (ABP) and other cardiovascular risk factor changes in 51 living donors over 12 months postdonation. Donors also provided 24‐h urine collections for monitoring protein and creatinine clearance, 75 g oral glucose tolerance tests (OGTT), and fasting lipids. Nondipping was defined as night‐day systolic (SBP) ratio ≥0.9. Baseline and 12‐month pre to postdonation comparisons were made both for dippers and nondippers. Of 51 donors, 35 were dippers and 16 nondippers. In these two groups, predonation 24‐h SBP were 115.2 ± 8 and 115.6 ± 10 mmHg; serum creatinine (SCr) 69.3 ± 12 and 71.1 ± 13 μmol/l; and 24‐h urine protein 0.12 ± 0.05 and 0.09 ± 0.03 g (all P = NS) while at 12 months, 24‐h SBP were 111.4 ± 11 and 114.3 ± 8 mmHg (P = 0.384), SCr 97.9 ± 16 and 97.7 ± 21 μmol/l (P = 0.810); and 24‐h urine protein 0.139 ± 0.09 and 0.111 ± 0.07 g/d (P = 0.360) respectively. The 24‐h SBP was significantly lower in the dippers at 12 months as compared with predonation (P = 0.036). OGTT and lipid profiles remained normal in both groups. Predonation nocturnal nondipping does not carry adverse postdonation consequences over 12 months.