Coexistence of primary pulmonary Hodgkin lymphoma and gastric MALT lymphoma associated with Epstein‐Barr virus infection: A case report |
| |
| Authors: | Kuniyuki Oka Mayumi Shinonaga Reizo Nagayama Hiroshi Kashimura Nobuo Yonekawa Sho Tatebe Setsuo Kuraoka Yasushi Yatabe Naoyoshi Mori |
| |
| Affiliation: | 1. Pathology,;2. Thoracic Surgery,;3. Hematology,;4. Gastroenterology, Mito Saiseikai General Hospital, Mito, Ibaraki,;5. Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya and;6. Pathology, Nakatsugawa City Hospital, Nakatsugawa, Gifu, Japan |
| |
| Abstract: | We describe a 66‐year‐old woman with Epstein‐Barr virus‐associated lymphoproliferative disorder with lung and gastric tumors. We identified two lung tumors measuring 13 and 20 mm in diameter that consisted of CD30‐, CD15‐, and CD20‐positive Hodgkin‐ and Reed‐Sternberg‐like cells and heterogeneous cellular infiltrates in a pronounced nodular pattern, with necrosis and vasculitis, diagnosed as nodular sclerosis classical Hodgkin lymphoma. A gastric tumor showed low‐grade extranodal marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue type. Neoplastic cells in all tumors expressed Epstein‐Barr virus‐encoded RNA based on in situ hybridization. The present case is a rare composite lymphoma arising from different extranodal organs, associated with EBV infection. Her medical history included gamma‐knife therapy for clinical diagnosis with a suspicion of cerebral lymphoma. |
| |
| Keywords: | Epstein‐Barr virus‐associated lymphoproliferative disorder gastric MALT lymphoma lymphomatoid granulomatosis pulmonary Hodgkin lymphoma |
|
|
