Association of plasma pentosidine concentrations with renal function in kidney graft recipients

Slowik‐Zylka D, Safranow K, Dziedziejko V, Ciechanowski K, Chlubek D. Association of plasma pentosidine concentrations with renal function in kidney graft recipients.
Clin Transplant 2010: 24: 839–847. © 2009 John Wiley & Sons A/S. Abstract: Background: Advanced glycation end‐products accumulate in the plasma of uremic patients. We aimed to assess the changes of free (P_free) and total (P_tot) plasma pentosidine concentrations in kidney graft recipients, create a model describing their profile and analyze associations with clinical parameters. Material and methods: We measured P_free and P_tot in the plasma of 12 non‐diabetic patients before and after kidney transplantation by HPLC. Results: P _tot concentrations were significantly decreasing after transplantation. The changes were well described by the exponential model assuming an asymptotic fall until the steady‐state concentration is attained. P_tot before and after transplantation displayed a strong negative correlation with mean daily diuresis (Rs = ?0.64, p < 0.05 before; Rs = ?0.94, p < 0.01 after 20 d). The rate of fall of the P_tot was positively correlated with the mean daily volume of urine passed in the second week after operation (Rs = +0.58, p < 0.05). Conclusions: The rate of fall of the P_tot after transplantation displays a strong correlation with diuresis, and the P_tot before transplantation is a potential prognostic factor for diuresis after the operation. Further prospective studies are necessary to demonstrate whether an effort to reduce carbonyl stress and pentosidine concentration before transplantation improves renal outcome.