Drug management in emergent liver transplantation of mitochondrial disorder carriers: review of the literature |
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Authors: | Youri Vater Gregory Dembo Kenneth Martay Yifat Klein Alex Vitin Avi A. Weinbroum |
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Affiliation: | 1. Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA;2. Post‐Anesthesia Care Unit, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel |
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Abstract: | Vater Y, Dembo G, Martay K, Klein Y, Vitin A, Weinbroum AA. Drug management in emergent liver transplantation of mitochondrial disorder carriers: review of the literature. Clin Transplant 2010 DOI: 10.1111/j.1399‐0012.2009.01203.x © 2010 John Wiley & Sons A/S. Abstract: Background: Mitochondrial respiratory‐chain disorders (MRCD) lead to progressive disabling of neurological and cellular conditions that involve muscles, brain, kidney, and liver dysfunction. Affected individuals may need surgery, including orthotopic liver transplantation (OLT). Surgery poses anesthesia challenges because of the prolonged use of anesthetic drugs and sedatives, which may inhibit oxidative phosphorylation, mimic mitochondrial cytopathic disorders, or unveil them ex novo. Materials and methods: We conducted a multilingual PubMed search of surgical and non‐surgical anesthesia reports between the years 1992 and 2008, where anesthetic drugs were used in MRCD patients, especially for those undergoing urgent OLTs. Results: There were 51 case reports of 210 anesthesia and critical care interventions in patients with MRCD, a large part of them were children. Data pertaining to the safe usage of anesthesia and perioperative drugs were limited and conflicting. We found no article that addressed the issue of perioperative handling of urgent OLT in MRCD patients. We therefore suggest our own – although limited – experience for such occasions. Conclusion: There are no randomized, controlled, trial‐based indications regarding safe anesthetic drugs to be used perioperatively in MRCD carriers. Consultation among geneticists, anesthesiologists, intensivists, and surgeons is essential in patients with known/suspected metabolic syndrome for planning appropriate perioperative care. |
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Keywords: | anesthesia drug safety liver failure mitochondrial disorders perioperative care transplantation |
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