Patient HSP70‐hom TG haplotype is associated with decreased transplant‐related mortality and improved survival after sibling HLA‐matched hematopoietic stem cell transplantation

Kim I, Kim JH, Rhee JY, Kim JW, Cho HJ, Cho E‐Y, Lee J‐E, Hong Y‐C, Park SS, Yoon S‐S, Park MH, Park S, Kim BK. Patient HSP70‐hom TG haplotype is associated with decreased transplant‐related mortality and improved survival after sibling HLA‐matched hematopoietic stem cell transplantation.
Clin Transplant 2010: 24: 459–466.
© 2009 John Wiley & Sons A/S. Abstract: Heat shock protein 70‐hom (HSP70‐hom) plays an important role in protein folding and immune responses. Therefore, HSP70‐hom gene polymorphisms may act as important factors in predicting the prognosis of patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). To evaluate the role of HSP70‐hom gene polymorphisms in the prognosis of patients receiving sibling human leukocyte antigen (HLA)‐matched allogeneic HSCT, the HSP70‐hom polymorphisms, T2437C and G2763A, were genotyped in 147 patients receiving sibling HLA‐matched allogeneic HSCT. Individual diplotypes were estimated from genotype data of the two HSP70‐hom polymorphisms using the expectation maximization algorithm. Patients with the 2763GG or GA genotype showed longer overall survival compared with those with the 2763AA genotype, and patients with a TG haplotype (TG/TA, TG/TG or TG/CG) also showed longer overall survival compared with those with a non‐TG haplotype (TA/TA or TA/CG) (both G2763A genotype and diplotype, p < 0.01). Moreover, the 2437TT genotype was found to be protective for treatment‐related death compared with the 2437TC genotype, and a TG haplotype was found to be very protective for treatment‐related death compared with a non‐TG haplotype (T2437C genotype, p = 0.04; and diplotype, p = 0.02). Therefore, our results suggest that HSP70‐hom polymorphisms play an important role in the prognosis of patients receiving sibling HLA‐matched allogeneic HSCT.