Parathyroid hormone‐related peptide‐producing non‐familial pheochromocytoma in a child |
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Authors: | Keisuke Takeda Noboru Hara Makoto Kawaguchi Tsutomu Nishiyama Kota Takahashi |
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Institution: | 1. Division of Urology, Department of Regenerative and Transplant Medicine, and;2. Division of Molecular Oncology, Department of Signal Transduction Research, Graduate School of Medical and Dental Sciences, Niigata University, and;3. Department of Pathology, Niigata Rousai Hospital, Joetsu, Niigata, Japan |
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Abstract: | We experienced a case of parathyroid hormone‐related peptide (PTHrP)‐producing pheochromocytoma, which was found in a 12‐year‐old boy with hypercalcemia. The leading symptom was abdominal pain, and severe hypertension and tachycardia were noticed at the initial visit. His medical and familial histories were unremarkable. Laboratory examinations showed hypercalcemia (3.3 mmol/L of serum‐calcium). Computed tomography showed a heterogeneous mass measuring 5.0 cm in the right adrenal gland, which had abnormal uptake with 123‐I metaiodobenzylguanidine scintigraphy. Serum/urine catecholamines were highly elevated, and serum PTHrP also increased (1.4 pmol/L). The patient underwent laparoscopic right adrenalectomy. The tumor was histologically diagnosed as typical pheochromocytoma and the expression of PTHrP was confirmed with immunohistochemistry. The serum PTHrP level was normalized after surgery. He was free of disease postoperatively for 12 months. There has been no described pediatric patient with PTHrP‐producing pheochromocytoma. We showed evidence that the present tumor is a complex neoplasm involving various neuroendocrine activities with the dual‐lineage differentiation. |
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Keywords: | childhood hypercalcemia parathyroid hormone‐related peptide pheochromocytoma sporadic |
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