Luminex‐based virtual crossmatching facilitates combined third‐time cardiac and de novo renal transplantation in a sensitized patient with sustained antibody‐mediated cardiac allograft rejection |
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| Authors: | Marcus‐André Deutsch Teresa Kauke Sebastian Sadoni Sieglinde Kofler Daniel Schmauss Amir K Bigdeli Max Weiss Bruno Reichart Ingo Kaczmarek |
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| Institution: | 1. Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig‐Maximilians‐University, Marchioninistrasse, Munich, Germany;2. Laboratory for Immunogenetics, University Hospital Grosshadern, Ludwig‐Maximilians‐University, Marchioninistrasse, Munich, Germany;3. Institute of Pathology, Campus Grosshadern, Ludwig‐Maximilians‐University, Marchioninistrasse, Munich, Germany |
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| Abstract: | Deutsch M‐André, Kauke T, Sadoni S, Kofler S, Schmauss D, Bigdeli AK, Weiss M, Reichart B, Kaczmarek I. Luminex‐based virtual crossmatching facilitates combined third‐time cardiac and de novo renal transplantation in a sensitized patient with sustained antibody‐mediated cardiac allograft rejection.Pediatr Transplantation 2010: 14:E96–E100. © 2009 John Wiley & Sons A/S. Abstract: Allosensitization represents a major obstacle to successful re‐transplantation since circulating antibodies can elicit antibody‐mediated rejection episodes with subsequent graft failure. Since sensitization is primarily considered a contraindication to transplantation the duration for patients waiting for a suitable donor organ to become available is considerably prolonged. Herein, we report on the successful application of a Luminex‐based virtual crossmatch approach to facilitate combined third‐time cardiac and de novo renal transplantation in a sensitized patient with sustained antibody‐mediated cardiac allograft rejection. |
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| Keywords: | sensitization HLA‐antibodies cardiac re‐transplantation renal transplantation virtual crossmatch |
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