Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients |
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Authors: | Ming‐Che Lee Chung‐Jen Lee Guan‐Jin Ho Chia‐Chi Lee Ming‐Hui Shih Kuei‐Chun Chou Bang‐Gee Hsu |
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Institution: | 1. School of Medicine, Tzu Chi University;2. Department of Surgical Oncology, Cancer Center;3. Department of Nursing, Tzu Chi College of Technology;4. Department of Surgery;5. Department of Nursing;6. Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan |
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Abstract: | Lee M‐C, Lee C‐J, Ho G‐J, Lee C‐C, Shih M‐H, Chou K‐C, Hsu B‐G. Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients.Clin Transplant 2010: 24: E124–E129.© 2010 John Wiley & Sons A/S. Abstract: Objective: Our aim was to evaluate the relationship between metabolic syndrome and fasting serum leptin concentration in renal transplant recipients. Patients and methods: Fasting blood samples were obtained from 55 renal transplant recipients. Metabolic syndrome and its components were defined using the diagnostic criteria of the International Diabetes Federation. Results: Thirteen patients (23.6%) had metabolic syndrome. Fasting leptin concentrations were positively correlated with metabolic syndrome (p = 0.003). Univariate linear regression analysis indicated fasting serum leptin values were positively correlated with waist circumference (r = 0.284; p = 0.036), body mass index (r = 0.358; p = 0.007), body fat mass (r = 0.610; p < 0.001), triglycerides (r = 0.268; p = 0.048), high‐sensitivity C‐reactive protein (hs‐CRP) (r = 0.377; p = 0.005), triceps skinfold (r = 0.335; p = 0.012), and mid‐arm fat area (r = 0.351; p = 0.009). Multivariate forward stepwise linear regression analysis of the significant variables revealed that body fat mass (R2 change = 0.373; p < 0.001) and hs‐CRP (R2 change = 0.045; p = 0.049) were the independent predictors of fasting serum leptin concentration. Conclusion: Serum leptin concentration correlates positively with metabolic syndrome in renal transplant recipients. |
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Keywords: | body fat mass high‐sensitive C‐reactive protein kidney transplantation leptin metabolic syndrome |
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