Relationship of non‐alcoholic fatty liver disease to colorectal adenomatous polyps |
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Authors: | Sang Tae Hwang Yong Kyun Cho Jung Ho Park Hong Joo Kim Dong Il Park Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Kyoung Hee Won Wook Jin |
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Affiliation: | 1. Division of Gastroenterology, Department of Internal Medicine, Sungkyunkwan University, School of Medicine, Seoul, South Korea;2. Suwon Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea and;3. Laboratory of Molecular Disease and Cell Regulation, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, South Korea |
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Abstract: | Background and Aims: Metabolic syndrome and insulin resistance are associated with a higher risk of colon cancer. Non‐alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver. This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps. Methods: We examined the 2917 participants who underwent a routine colonoscopy at Kangbuk Samsung Hospital in 2007. We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361). Anthropometric measurements, biochemical tests for liver and metabolic function, and abdominal ultrasonographs were assessed. Results: The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group. By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03–1.60). An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps. Conclusion: NAFLD was associated with colorectal adenomatous polyps. Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer. |
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Keywords: | colorectal adenomatous polyp non‐alcoholic fatty liver disease |
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