Bioavailability of calcium from oyster shell electrolysate and DL-Calcium lactate in vitamin D-replete or vitamin D-deficient rats |
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Authors: | Toshio Okano Tamiko Kimura Naoko Tsugawa Yukiko Oshio Yumiko Teraoka Tadashi Kobayashi |
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Institution: | (1) Department of Hygienic Sciences, Kobe Women's College of Pharmacy, 4-19-1 Motoyamakita-machi, Higashinada-ku, 658 Kobe, Japan |
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Abstract: | Bioavailability of calcium (Ca) from oyster shell electrolysate (Active Absorbable Ca: AACa) and DL-Ca lactate in rats was
investigated. Plasma Ca metabolism, bone mineral density and vitamin D-deficient rats were measured and compared each other.
Vitamin D-deficient rats were fedad libitum a vitamin D-free diet containing 0.44 % Ca or 1.20 % Ca adjusted with either AACa or DL-Ca lactate with or without oral supplementation
of physiological dose (10 IU/rat/day) of vitamin D3 for 28 days. During and after feeding, concentrations of Ca, phosphorus, parathyroid hormone (PTH), 25-hydroxyvitamin D3 (25-OH-D3), 1α, 25-dihydroxyvitamin D3 1, 25(OH)2D3] and alkaline phosphatase (Alp) activity in plasma were measured. Furthermore, femoral Ca and phosphorus contents, mineral
density and mechanical strength were also measured. Despite of the differences of contents and chemical forms of Ca in diets,
all the groups showed prompt and complete recoveries in both Ca and vitamin D malnutritions under vitamin D-replete condition
and there was no significant difference among all the groups in increases of body weight gains and plasma Ca levels, and in
decreases of plasma PTH level and Alp activity. In contrast, the groups fed the same diets under vitamin D-deficient condition
showed no significant recoveries in both plasma Ca metabolism and bone mineralization although Ca bioavailability of AACa
appeared to be slightly better than that of DL-Ca lactate. These results suggest that bioavailability of Ca from AACa and
DL-Ca lactate are substantially equal in increasing plasma Ca levels, bone mineral density and mechanical strength in both
vitamin D-replete and vitamin D-deficient rats. |
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Keywords: | Oyster shell electrolysate(Active absorbable Ca:AACa) DL-Ca lactate bioavailability of Ca plasma Ca metabolism and bone mineralization vitamin D-replete or vitamin D-deficient rats |
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