| 碘杂环化合物-72对异丙肾上腺素、氯化钙和组胺收缩豚鼠心室肌效应的影响 |
| |
| 引用本文： | 姬广聚,赵德化,刘德强,盛宝恒. 碘杂环化合物-72对异丙肾上腺素、氯化钙和组胺收缩豚鼠心室肌效应的影响[J]. 医学争鸣, 1992, 0(3) |
| |
| 作者姓名： | 姬广聚 赵德化 刘德强 盛宝恒 |
| |
| 作者单位： | 第四军医大学药理学教研室，第四军医大学药理学教研室，第四军医大学药理学教研室，第四军医大学药理学教研室 总后医学专科学校药理学教研室 北京 100071 |
| |
| 摘 要： | 作者用豚鼠右心室乳头状肌标本(n=20),观察了IHC-72对异内肾上腺素、氯化钙和组胺所致收缩张力量效反应的影响,结果,IHC-72使异丙肾上腺素量效曲线非平行右移,其pD_2值为3.94;IHC-72也使氯化钙和组胺量-效曲线右移,pD_2值分别是4.26和4.15实验结果提示,IHC-72作用类似verapamil,可阻滞心肌细胞膜Ca~(2+)内流.
|
| 关 键 词： | 心律失常 碘杂环化合物72 乳头状肌 异丙肾上腺素 氯化钙 组胺 |
Effects of IHC-72 on the ventricular muscle contraction induced by isoproterenol, calcium and histamine in guinea pigs |
| |
| Guang-Ju,ZHAO De-Hua,LIU De-Qiang and SHENG Bao Heng. Effects of IHC-72 on the ventricular muscle contraction induced by isoproterenol, calcium and histamine in guinea pigs[J]. Negative, 1992, 0(3) |
| |
| Authors: | Guang-Ju ZHAO De-Hua LIU De-Qiang SHENG Bao Heng |
| |
| Affiliation: | Guang-Ju,ZHAO De-Hua,LIU De-Qiang and SHENG Bao Heng Department of Pharmacology |
| |
| Abstract: | The effects of 3,6 (dimethylamino) - dibenxopyriodomum cdetate (IHC 72) on the dose-response curves of isoproterenol, calcium and histamine in guinea-pig papillary muscles were studied. When isoproterenol dose-response curves were shifted 10 the right, the maximal response was depressed, the pD2 value was 3.94; IHC -72 and verapamil antagonized the effect of calcium non-compctively, the pD. values were 4.26 and 5.60 respectively. IHC-72 could also make the dose-response curves of histamine shift to right in a non-parallel manner, the pD, value was 4.15. The results indicate that the eflect of IHC-72 on the guinea-pig papillary muscle is similar to that of verapamil, that is, it may influence Ca2+ movement in myocardial cells. |
| |
| Keywords: | arrhythmia 3. 6 - (dimethylamino) - dibenwpyriodonium edctate papillary muscle isoproterenol calcium chloride histamme |
| 本文献已被 CNKI 等数据库收录！ |
|
