灯盏花素对感染性休克合并肾损伤患者的临床疗效分析

目的：探讨灯盏花素对感染性休克合并肾损伤患者尿肾损伤分子‐1（Kim‐1）与中性粒细胞明胶酶相关脂质运载蛋白（NGAL）表达的影响，以及其对肾功能的保护作用。方法选取该院2013年5月至2015年5月重症监护室（ICU）收治的感染性休克合并急性肾损伤（AKI）确诊患者66例，按随机数字表法将其分为干预组与对照组，各33例。所有患者均行感染性休克的规范化治疗，干预组在此基础上给予灯盏花素静脉滴注，比较两组的临床治疗效果。结果干预组患者尿Kim‐1、NAGL水平治疗后1d均上升，从治疗3d开始Kim‐1、NAGL水平逐渐下降，治疗3、5、7、9d后尿Kim‐1、NAGL水平与对照组比较，差异均有统计学意义（P＜0．05）；干预组中5例患者死亡，对照组中6例死亡；对照组ICU住院时间、需要透析的患者例数、透析治疗次数及透析治疗时间均多于干预组，差异均有统计学意义（P＜0．05）。结论灯盏花素可以降低感染性休克合并肾损伤患者尿Kim‐1与NGAL的表达，促进肾功能的恢复。

Analysis on clinical effect of breviscapine in patients with septic shock complicating acute renal injury

Objective To investigate the effects of breviscapine on the expression of urine Kim‐1 and NGAL in the patients with septic shock complicating renal injury .Methods A total of 66 cases patients with septic shock complicating acute kidney inju‐ry(AKI) in our hospital from May 2013 to May 2015 were selected and randomly divided into the intervention group and control group according to the random number table ,33 cases in each group .All cases were given the standardized therapy of septic shock . On this basis the intervention group was given the intravenous drip of breviscapine .The clinical curative effects were compared be‐tween the two groups .Results The level of Kim‐1 and NAGL were risen after 1 d of treatment ,but began to gradually drop on 3 d of treatment ,the levels of Kim‐1 and NAGL on 3 ,5 ,7 ,9 d had statistical differences between the two groups (P<0 .05);in the in‐tervention group ,5 cases died ,while 6 cases in the control group died .The ICU stay time ,cases number needing dialysis ,dialysis times and dialysis curative time in the control group were more than those in the intervention group ,the differences were statistical‐ly significant(P< 0 .05) .Conclusion Breviscapine could reduce the expression of Kim‐1 and NGAL in the patients with septic shock complicating AKI and promote the recovery of renal function .