晚期胃癌患者抑郁与生存质量的现状及相关性分析

目的：了解晚期胃癌患者的抑郁与生存质量的状况，并探讨二者的相关关系。方法采用抑郁自评量表（SDS ）和世界卫生组织生存质量测定量表简表（WHOQOL‐BREF）对131例晚期胃癌患者进行问卷调查，并与健康人群的调查结果进行比较。结果131例晚期胃癌患者的抑郁发生率为47．33％，SDS平均得分为（45．99±15．47）分，高于健康人群。晚期胃癌患者的生存质量得分为：生理领域（61．61±12．66）分，心理领域（59．54±12．49）分，社会关系领域（64．95±14．16）分，环境领域（52．93±14．07）分，均低于健康人群。抑郁得分与生存质量4个领域的评分均有显著的相关性，其中，与心理领域的相关性最强相关系数（ r）＝－0．636，决定系数（ r2）＝0．405]。结论晚期胃癌患者的抑郁程度较高，生存质量较差，二者具有相关性。其中，抑郁与心理领域的相关性最强。

Analysis on current situation of depression and quality of life in patients with advanced gastric cancer and their correlation

Objective To understand the status of depression and quality of life in the patients with advanced gastric cancer , and to explore their relationship .Methods The depression self rating scale (SDS) and the Chinese Scale of World Health Organiza‐tion Quality of Life Scale‐Brief Form Questionnaire (WHOQOL‐BREF) were adopted to conduct the questionnaire investigation on 131 patients with advanced gastric cancer ,then the results were compared with those of the health population .Results Among 131 patients with advanced gastric cancer ,the prevalence rate of depression was 47 .33% ,and the average SDS score was 45 .99 ± 15 .47 ,which were higher than those of the health population .The scores of quality of life were 61 .61 ± 12 .66 for the physiologic health domain ,59 .54 ± 12 .49 for the mental health domain ,64 .95 ± 14 .16 for the social relation domain and 52 .93 ± 14 .07 for the surrounding environment domain .There was a significant correlation between the depression score with the four domains scores of life quality ,in which the correlation with the mental health domain was strongest (r= -0 .636 ,r2 =0 .405) .Conclusion High depression level and poor quality of life exist in the patients with advanced gastric cancer ,and there is a correlation between them , in which the correlation between depression with the mental health domain is strongest .