| 拉米夫定抗乙型肝炎病毒作用评价 |
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| 引用本文： | 张旭东,蔡温儒,吴惠珍. 拉米夫定抗乙型肝炎病毒作用评价[J]. 中国医院用药评价与分析, 2001, 1(2): 85-86 |
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| 作者姓名： | 张旭东 蔡温儒 吴惠珍 |
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| 作者单位： | 河北省人民医院, |
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| 摘 要： | 目的评价拉米夫定在乙型肝炎病毒（HBV）感染者治疗中的临床疗效和安全性。方法查阅近几年有关中、外文献并结合自身临床实践，进行分析、评价。结果拉米夫定能快速高效降低乙型肝炎病毒脱氧核糖核酸（HBV－DNA）水平。用于慢性乙型肝炎（CHB）及活动性肝硬化患者疗效较好，用于HBeAg阳性及丙氨酸转氨酶（ALT）正常的携带者的治疗效果不佳。结论拉米夫定是治疗CHB的高效药物，应用方便、安全，不良反应少且轻微，耐受性好。
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| 关 键 词： | 拉米夫定；乙型肝炎病毒；乙型肝炎病毒脱氧核糖核酸；慢性乙 |
| 文章编号： | 2001－02－0085－02 |
| 修稿时间： | 2001-04-04 |
Evaluation of the Anti |
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| ZHANG Xudong,CAI Wenru,WU Huizhen. Evaluation of the Anti[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2001, 1(2): 85-86 |
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| Authors: | ZHANG Xudong CAI Wenru WU Huizhen |
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| Abstract: | OBJECTIVE: To evaluate the clinical efficacy and safty of lamivudine in treatment of patients with HBV infections. METHODS: The analysis and evaluation were based on the review of literature, published in recent years, in combination with our clinical experience. RESULTS: Lamivudine could rapidly decrease the level of HBV-DNA in patients with hepatitis B and showed good therapeutic effect on chronic hepatitis B and active hepatocirrhosis, however, the effect was unsatisfactory on the carrier with positive HBeAg and normal ALT. CONCLUSION: Lumivudine is an effective agent in treating chronic hepatitis B and it is simple in use, safe, slight in ARDs and tolerable to patients. |
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| Keywords: | lamivudine HBV HBV-DNA chronic hepatitis B |
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