Effects of chlorpromazine on acquisition and extinction of a conditioned response in mice |
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| Authors: | Denenberg Victor H Ross Sherman Ellsworth Joanne |
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| Institution: | (1) Roscoe B. Jackson Memorial Laboratory, Purdue University, USA;(2) University of Maryland, USA;(3) Department of Psychology, Purdue University, USA;(4) Department of Psychology, University of Maryland, USA;(5) Present address: Department of Psychology, University of Chicago, USA |
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| Abstract: | Summary Mice acquired a tone-shock association under conditions of saline injections, or an injection of 1.5 mgm./kgm. or 4.5 mgm./kgm. of chlorpromazine. Five days later the Ss were tested for retention of the response by being given extinction trials. Each of the three groups were divided and received either a saline injection or an injection of 1.5 mgm./ kgm. chlorpromazine just prior to extinction testing.A significant linear dose response function was obtained between amount of chlorpromazine injected during acquisition and performance under extinction, with the saline group requiring the greatest number of trials to extinguish. The presence or absence of chlorpromazine during extinction did not affect performance, nor was there any interaction between drug levels during acquisition and drug levels during extinction.This study was supported in part by a research grant, M-1604, from the National Institute of Mental Health to the University of Maryland.Summer College student |
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