镁对糖尿病鼠视网膜组织cAMP的影响

21只SD鼠用链脲佐菌素制作糖尿病模型。分别给予自来水、0.5%硫酸镁液饮用和按0.1g/kg体重每月肌肉注射硫酸镁1次。发现凡给予镁的动物，其生长发育良好，体重稳步增加。饮0.50%硫酸镁的SD鼠视网膜中cAMP含量明显高于引自来水的糖尿病鼠，与正常对照组相似。提示镁对改善糖尿病鼠的全身代谢起了一定作用。（中华眼底病杂志，1992，8：141-143）

THE ROLE OF MAGNESIUM IN cAMP LEVEL IN RETINA OF DIABETIC RATS

Tweenty-one SD rats with streptozotocin-induced diabetes were investigated for the influence of magnesium in cAMP level in the retina of the diabetic rats. The diabetic rats were divided into 3 groups: group 1, drinking tap hehwater; group 2, drinking 0.5% MgSO4 solution and group 3, receiving intramuscular MgSO4(0.1g/kg) once a month. In addition, group 4, a controlgroup of normal nondiabetic rats fed with tap water. In aperiod of 5 months examination, the growth and health conditions of diabetic rats were found to be nearly normal in group 2, 3 and 4, manifested by gaining weight and soft, smooth hairs on the skin, in contrast with loss in weight, rough hairs and even dying of infection in 2 of the diabetic rats in group 1. furthermore, the level of cAMP content in retina was found significantly higher in the diabetic rats taking Mg++ in spite of the route of administration(group 2, 3), as well as in the control group(group 4) than that of the diabetic rats which were fed with tap water. These results demonstrated that Mg++ might play an important role in improving the metabolism of diabetic rats including the retinal tissue by influencing the level of cAMP content, which is necessary in nuclear acid metabolism, protein synthesis, proliferation and differentiation, and other intracellular metabolic processes. （Chin J Ocul Fundus Dis,1992,8:141-143）