| 血清1,25-(OH)_2-D_8放射受体检测技术及其在佝偻病研究中的应用 |
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| 引用本文： | 石育原,张培因,李亚娟,李晓梅,麦荫乔,于贵,李维海. 血清1,25-(OH)_2-D_8放射受体检测技术及其在佝偻病研究中的应用[J]. 吉林大学学报(医学版), 1988, 0(3) |
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| 作者姓名： | 石育原 张培因 李亚娟 李晓梅 麦荫乔 于贵 李维海 |
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| 作者单位： | 白求恩医科大学基础医学部(石育原，张培因，李亚娟，李晓梅，麦荫乔)，辽源市妇婴医院(于贵)，长春市市立二院(李维海) |
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| 摘 要： | 采用改良的放射受体测试技术,建立了一种灵敏、稳定、快速、精确的血清1,25-(OH)_2-D_3(1,25—Dihydoxyvitamin D_3,Dihydroxycholecalciferol,DHCC)检测方法,并应用于先天性佝偻病及青春期佝偻病的临床研究,佝偻病观察组血清DHCC含量显著低于正常对照组,且对佝偻病的检出率显著高于低钙征、血生化检查及X线检查,故血清DHCC检测可作为佝偻病灵敏而特异的早期诊断指标。基于新生儿血清DHCC含量与其母体紧密相关,检测孕妇血清DHCC含量,可作为诊断、防治先天性佝偻病的重要依据。
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| 关 键 词： | 二羟维生素D_3 佝偻病 放射受体测定 |
Radioreceptor assay for 1,25-Dihydroxyvitamin D_3 in serum and its application in the study of rachitis |
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| Shi Yuyuan,Zhang Peiyin,Li Yajuan,Li Xiaomei Mai Yinqiao,Yu Gui and Li Weihai. Radioreceptor assay for 1,25-Dihydroxyvitamin D_3 in serum and its application in the study of rachitis[J]. Journal of Jilin University: Med Ed, 1988, 0(3) |
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| Authors: | Shi Yuyuan Zhang Peiyin Li Yajuan Li Xiaomei Mai Yinqiao Yu Gui Li Weihai |
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| Affiliation: | Department of Basic Medical Sciences |
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| Abstract: | A modifed radioreceptor assay for 1,25-(OH)2-D3 (1,25-Dihydroxy vitamin D3, Dihydroxycholecalciferol, DHCC) in serum was established, which was proved to have high sensitivity, stability and accuracy, and wasj applied in patienss with rachitis. The results showed that DHCC level in serum in rachictic patients was lower than of the control.The detection rate of DHCC was obviously higher than that through symptoms, liboratory tests and X-ray examination in patients with rachitis .Therefore, this assay technique can be used as a sensitive indicator for diagnosis of rachitis.It was also found that DHCC level in mothers was correlative with their infants, so that assay for DHCC level in pregnant mothers has significance in prevention and treatment of rachitis in their infants. |
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| Keywords: | 1 25-Dihydroxyvitamin D3 Rachitis Radioreceptor assay |
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